Record of the discussion that took place at the latest SAGE meeting on 13 January 2022.


Professor Chris Whitty and Patrick Valance at a cabinet meeting at the FCO during Covid-19. | Flickr/Number 10 - Andrew Parsons

Situation update


CHANGES IN TESTING POLICY AND BEHAVIOUR CREATED UNCERTAINTY

“There is uncertainty about current trends in the number of new infections, particularly as a result of changes to testing policy and behaviours. This includes differences in people’s approach to testing before and after Christmas. The ONS infection survey will continue to be the most reliable measure of infections and therefore the best way of identifying whether a peak has occurred. These prevalence data lag the number of new infections, so the national peak will not be reliably identified until after it has passed. Many infections will occur after the peak has been reached, with the total number depending on how rapid the decline is. Trends in the number of positive tests reported remain a useful additional measure for understanding infection levels.”

HOSPITAL ADMISSIONS LEVEL OVERALL

The number of hospital admissions in England is level overall, though with differences between regions. Admissions are declining in London but increasing in the North of England where levels are now comparable to previous peaks. An increasing proportion of these reported admissions are positive tests amongst people admitted primarily for reasons other than COVID-19, reflecting the very high community prevalence.”

LOWER NEED OF ICU

A decreasing proportion of those in hospital require ICU admission, which suggests that the reduction in severity if measured by ICU admission risk is even greater than the reduction when measured by hospital admission risk. This appears to be particularly the case in a highly immunised population; in some parts of the USA and Europe where immunity levels are lower there have been increases in hospital and ICU admissions more in line with infection levels. Further analysis will be better able to assess the severity reduction in the UK for Omicron compared to Delta with ICU admission and use of ventilation as endpoints when more data are available.”

A SHORTER GENERATION TIME

There is increasing evidence that the generation time for Omicron is shorter than for Delta. As previously noted, a shorter generation time will result in an earlier and lower peak in infections and hospital admissions for a given growth rate and probably greater impact of interventions. There is also some evidence that the range of generation times might be wider.”

Xtra

“Generation time” is the number of days that elapse between the moment someone is infectious and when someone they infect also becomes infectious.


NO INCREASE IN HOSPITAL ADMISSIONS SO FAR

The increase in hospitalisations, which is anticipated following the observed increase in cases in older age groups, has not been seen so far. This may be due to higher vaccine levels of protection against hospitalisation, slower waning of vaccine protection, or the impact of precautionary behaviours amongst the most vulnerable and those around them. Analysis from Bristol shows that intended behaviour change over December 2021 has led to lower modelled numbers of infections over recent weeks (compared to no such risk mitigation). Changes in community treatment may also have had a small effect on hospital admission numbers. A combination of these factors is also possible.”

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UNCERTAIN COMING WEEKS FOR HOSPITAL ADMISSIONS

“The medium-term projections produced by SPI-M-O show what might happen if recent trends continue. These do not reflect the impact of potential behavioural or policy changes (for example as a result of any reversal of Plan B measures in England or changes to duration of isolation). There is uncertainty about what may happen to hospital admissions over the coming weeks, even in the absence of any such changes.

“Even if hospitalisations decrease nationally, trends may be different in different places and the health system may be under greater pressure in some areas. It also remains possible that admissions nationally could still increase further or could plateau at high levels for some time.”

BA.2 VARIANT MONITORED

UKHSA continues to monitor variants including the BA.2 variant of Omicron (which is S-gene target positive). There is currently no evidence of BA.2 having a faster growth rate than the now widespread BA.1 variant. Delta is now at low levels, in part because of the effects of the booster vaccination programme. It is not yet clear what protection is conferred against infection and disease from other variants following an Omicron infection; this will be important to establish for longer-term trajectories.”

CHILDREN HOSPITALIZATION INCREASING

Data continue to show relatively increased paediatric hospital admissions with COVID-19, especially for those under 1 year old, though it remains the case that most of these children have very short stays in hospital and are not severely ill. The number of admissions, including to intensive care, remains low compared to the usual level of admissions observed with other respiratory viruses at this time of year. Encouraging vaccination uptake in pregnant women should remain a priority.”

“No impact of Omicron on incidence of the COVID-19 associated multisystem inflammatory syndrome PIMS-TS can yet be observed, but cases typically present several weeks after infection so this cannot be excluded at this point. It is notable that in CO-CIN data, for the most recent month, there were no vaccinated 12 to 17-year-olds in HDU or ICU compared to 20 unvaccinated in the same age group. Further analysis would be required to fully assess the impact of vaccination on likelihood of ICU admission. The overall risk to children from COVID-19 remains very low (high confidence).”

Xtra

Paediatric Inflammatory Multisystem Syndrome (PIMS) is a new condition that happens weeks after someone has had the virus that causes coronavirus (COVID-19). It causes inflammation (swelling) throughout the body which is one way your immune system fights off infection, injury and disease.

(Source: Great Ormond Street Hospital for Children)


“Work is underway to understand the increased number of diagnoses of type 1 diabetes in children, and the potential association with SARS-CoV-2 infection.”

STRONG EVIDENCE MEASURES SUCH AS VENTILATION WORK

“Work is also underway to review emerging evidence on survival of SARS-CoV-2 in aerosols, though there remains strong evidence for the effectiveness of measures such as ventilation.”


Notes

This is a record of the discussion of SAGE 103 on 13 January 2022. The paper is the assessment of the evidence at the time of writing. As new evidence or data emerges, SAGE updates its advice accordingly.

These documents are released as pre-print publications that have provided the government with rapid evidence during an emergency. These documents have not been peer-reviewed and there is no restriction on authors submitting and publishing this evidence in peer-reviewed journals.

(Source: Scientific Advisory Group for Emergencies)


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